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$1,248,000

643 Grand Avenue, South San Francisco, CA 94080

30% above the South San Francisco median of $957K (28 active listings)

18% of South San Francisco listings have cut their price · half have been listed 30+ days

3beds
4baths
1,630sqft
$766/sqft

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About this home

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Property details

Property type
Single Family
Year built
1895
Lot size
3,500 sqft
Garage spaces
2
Stories
2
County
San Mateo
Listed
2 days ago
MLS #
82059314
Listed by
Jill Penna · Christie's International Real Estate Sereno

Features

  • Detached Garage
  • On Street
  • Central Forced Air
  • Roof: Shingle
  • Skylight
  • Walk-in Closet
  • Utilities: Public Utilities
  • Sewer: Sewer - Public
  • Water: Public
  • Water: Water Softener - Owned

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Location

Approximate location based on the listing address.

Copyright 2026 MLSListings Inc. Based on information from MLSListings MLS as of 8/28/2026. All data, including all measurements and calculations of area, is obtained from various sources and has not been, and will not be, verified by broker or MLS. All information should be independently reviewed and verified for accuracy. MLS Listing #82059314. Listing courtesy of Christie's International Real Estate Sereno.